Central and Peripheral Mechanisms of Neurodegeneration - UMR_S 1118

Key words

Neurobiology – Neurodegenerative diseases – Molecular biology – Cell biology – Motor neurones – Muscles – Metabolism


This research unit is part of the Laboratory of Molecular Signalling and Neurodegeneration, which conducts multidisciplinary research on neurodegenenerative diseases. Its researchers actively collaborate with Strasbourg hospitals and various institutions across France and Europe. The unit’s biomedical work is focused on therapeutical and aspects and diagnosis of dementia ( Alzheimer’s for instance) and Amyotrophic lateral sclerosis. Its fundamental research includes the development of new techniques in molecular biology, biochemistry and histology.

Research focus

Research is organised around five projects :

  • Energetic metabolism and motor neurone diseases  
  • ALS diagnostical and therapeutical  biomarkers
  • Modifications in epigenetic programs and neurodegenerative diseases
  • Stress signaling in the nervous system and the role of p53 proteins
  • Development and characterisation of new animal models of neurodegenerative diseases


Jean-Philippe Loeffler


Mécanismes centraux et périphériques de la neurodégénérescence
Faculté de médecine
11 rue Humann
67085 Strasbourg Cedex

Tél : 03 68 85 31 72

Établissement associé de l'Université de Strasbourg
Fondation Université de Strasbourg
Investissements d'Avenir
Inserm Grand Est
Ligue européenne des universités de recherche (LERU)
EUCOR, Le Campus européen