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A giant molecule to fight Ebola virus?

Publication date: 10/11/15


An international team of chemists has developed a method to synthesize mega-molecules endowed with antiviral activity.
These giant molecules are highly effective in inhibiting the entry of Ebola virus into cells in culture: their myriad branches (up to 120) carry sugars that bind strongly to the receptor used as a portal of entry by the virus. These findings open the way to potential applications to other pathogens (such as the AIDS or dengue viruses. This work is a collaboration between chemists from the CNRS, the University of Strasbourg, Madrid's Universidad Complutense and Laboratorio de Microbiología Molecular, Universidad de Sevilla and Université de Namur. It was published on 9 November 2015 in Nature Chemistry.


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